Healthcare Professionals

This is an international website for NERLYNX® dedicated to Healthcare professionals

IMPORTANT: the information on this website is based on the European Summary of Product Characteristics. Prescribing Information and indication may vary per country. You must refer to your country prescribing information. Please be aware we do not take responsibility for accessing such information which may not comply with the regulation or usage in your country.

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heading-Nerlynx-Neratinib--HER2-Breast-Cancer-2

Possible clinical scenarios

NERLYNX can be used as extended adjuvant therapy for selected patients*³⁷

Nerlynx-Neratinib--HER2+/HR+ early breast cancer- Adjuvant treatment history

Summary of the possible clinical scenarios taking into account therapeutic advances and acknowledging the different levels of evidence for NERLYNX use.³⁷

CT, chemotherapy; eBC, early breast cancer; HR, hormone receptor; HER2+, human epidermal growth factor receptor 2 positive; pCR, pathological complete response; T-DM1, trastuzumab emtansine.
Figure adapted from Untch M, et al. How to Optimise Extended Adjuvant Treatment with Neratinib for HER2+ Early Breast Cancer Patients. Oncol Ther J. 2021.
*Following trastuzumab-based treatment in HER2+ eBC, upon integration with existing treatment guidelines and careful benefit/risk evaluation on an individual patient basis.³⁷

Learn about…

NERLYNX
Efficacy

NERLYNX
Safety

NERLYNX
Dosing

Contenu de la pop in (ici, un H3)

A noter que le contenu de la pop in est prise en compte pour le SEO.

Il est donc nécessaire de bien baliser les titres. Nous conseillons d'utiliser un H2 ou un H3 (pas de H1).

▼ This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions.
This medicinal product is subject to risk minimization measures.

References
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3. Martin M, et al. Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol. 2017;18(12):1688−1700.
4. Holmes FA, et al. Continued efficacy of neratinib in patients with HER2-positive early-stage breast cancer. Final overall survival analysis from the randomized phase 3 ExteNET trial. Presented at the San Antonio Breast cancer Symposium. December 8-11, 2020. #PD3-03.
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21. Barcenas CH, et al. Improved tolerability of neratinib in patients with HER2-positive early-stage breast cancer: the CONTROL trial. Ann Oncol. 2020;31(9):1223−1230.
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31. Bradley R, et al. EBCTCG. Trastuzumab for early-stage, HER2-positive breast cancer: a meta-analysis of 13864 women in seven randomised trials. Lancet Oncol 2021; 22: 1139-50.
32. Loibl S, et al. VP6-2022 : Adjuvant pertuzumab and trastuzumab in patients with early HER-2 positive breast cancer in APHINITY: 8.4 years’ follow-up. Ann Oncol. 2022.
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This is an international website for NERLYNX®. IMPORTANT: the information on this website is based on the European Summary of Product Characteristics. Prescribing Information and indication may vary per country. You must refer to your country prescribing information. Please be aware we do not take responsibility for accessing such information which may not comply with the regulation or usage in your country.

Last update: 01/2023

Healthcare Professionals​

Non Healthcare Professionals

Possible clinical scenarios

NERLYNX can be used as extended adjuvant therapy for selected patients*37