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https://www.pierre-fabre.com/en
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heading-Nerlynx-Neratinib--HER2-Breast-Cancer

HER2+ / HR+ early breast cancer

Breast cancer epidemiology

Breast cancer is the most common cancer in women, with more than 2 million new cases each year worldwide.

Amplification or overexpression of HER2 occurs in approximately 15–30% of breast cancers.15
Around 80% of breast cancers test positive for ER, with 65% of these also testing positive for PR.29
Around 10% of breast cancers are HER2+/HR+.30

Breast cancer in females by subtype (%)30 :

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HR-/HER2+ 4% - HR-/HER2+ 4% - HR-/HER2-HR+/HER2-Unknown

 

Risk considerations in HER2+/HR+ early breast cancer

Without further treatment, 20-30% of patients with HER2+/HR+ disease will experience disease recurrence within 10 years of completing trastuzumab-based therapy. 1-3,6,7,31-36

Residual risk of recurrence for HER2+/HR+ (%) 3 years 4 years 5 years 6 years 10 years
Joint analysis (NCCTG, N9831, NSABP B-31)31,32,a
(adjuvant trastuzumab)
- 11 - - 24

HERA6,33,b 
(adjuvant trastuzumab)

10 - - - 28

APHINITY34,35,b
(adjuvant trastuzumab + pertuzumab)

5 - -
9
-
KATHERINE7,c
(post-neoadjuvant T-DM1)
9 - -

-

-
ExteNET control arm in HER2+/HR+, 1 year since trastuzumab therapy population1,d
(adjuvant trastuzumab)
- - 14 - -

HER2, human epidermal growth factor receptor 2; HR+, hormone receptor positive.
a Recurrence refers to DFS, defined as the time from enrolment to documentation of the first of any of these events: local, regional or distant recurrence of breast cancer; a contralateral breast cancer; a second primary cancer; or death as a result of any cause.32
b Recurrence refers to DFS, defined as the time from randomisation to the first occurrence of any of these events: recurrence of breast cancer at any site; the development of ipsilateral or contralateral breast cancer, including ductal carcinoma in situ but not lobular carcinoma in situ; second non-breast malignant disease other than basal-cell or squamous-cell carcinoma of the skin or carcinoma in situ of the cervix; or death from any cause.36
c Recurrence refers to iDFS, defined as time from randomisation to the first occurrence of any of the following events: recurrence of ipsilateral invasive breast tumour, recurrence of ipsilateral locoregional invasive breast cancer, contralateral invasive breast cancer, a distant disease recurrence or death from any cause.7,34
d Recurrence defined as the first occurrence of any of the following events: recurrence of ipsilateral invasive breast tumour, recurrence of ipsilateral locoregional invasive breast cancer, contralateral invasive breast cancer, a distant disease recurrence, or death from any cause.

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